We have chosen to study Alanine for its highly non polar nature, and Glutamine for its highly polar characteristic.
#OPTIMAGE POLYCRYSTALLINE POWDER COST SERIES#
We developed a method of generating an alpha-helix conformation of any residue using AMBER 4.0, the Protein Data Bank (PDB), and a series of pattern matching translation and rotation operations. The notion that secondary structures form first before long range tertiary contacts are made, suggests that the helix-coil interconversion is one key in understanding the protein folding problem. Recent laser-induced experiments have shown that on the time scale of long range tertiary contact formation, the kinetics of the helix-coil interconversion are very rapid (1). Such co-polymers might be useful in drug-delivery systems and other biomedical applications.Įffective harmonic approach to helix proteins The co-polymers could take up some water and the capacity was dependent on the ratio of poly(L-alanine) block to MPEG.
Two melting points from MPEG block and poly(L-alanine), respectively, could be observed in differential scanning calorimetry curves of the co-polymers, suggesting that a micro-domain phase separation appeared in their bulky states. According to circular dichroism measurement, the poly(L-alanine) chain on the co-polymers in an aqueous medium had a alpha-helix conformation. Their chemical structures were characterized on the basis of infrared spectrometry and nuclear magnetic resonance. The weight ratio of two blocks in the co-polymers could be altered by adjusting the feeding ratio of NCA to MPEG-NH2. The ring-opening polymerization of N-carboxy-L- alanine anhydride (NCA) in dichloromethane was initiated by amino-terminated poly(ethylene glycol) monomethyl ether (MPEG-NH2, M(n) = 2000) to afford poly(L-alanine)-block-MPEG. Zhang, Guolin Ma, Jianbiao Li, Yanhong Wang, Yinongĭi-block co-polymers of poly(L-alanine) with poly(ethylene glycol) monomethyl ether (MPEG) were synthesized as amphiphilic biodegradable co-polymers.
Synthesis and characterization of poly(L-alanine)-block-poly(ethylene glycol) monomethyl ether as amphiphilic biodegradable co-polymers.
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